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Pharmaceutical Drilling

Pharmaceutical Drilling

High-speed, reliable laser systems for pharmaceutical tablet drilling

Laser drilling is a proven, economically viable way to create sub-millimeter apertures in pharmaceutical tablets. These apertures play an important role in modern drug delivery systems, which provide many health benefits like decreasing dosing frequencies, achieving consistent drug concentrations in the blood and enabling customized delivery profiles.

Osmotic drug delivery systems are especially valuable, as they control the release of medication into the body. Pharmaceutical tablets for these systems are made in layers—including an indigestible coating, medication, a possible second coating and more medication. Lasers drill through the various layers—creating an aperture or pattern of apertures that release the medication into the stomach. You can meter the medication’s release by varying the size and number of apertures.

Why Laser Drilling is Important for Time-release Medication

Laser tablet drilling is a largely self-operating process that visually verifies aperture accuracy even at speeds of 140,000 tablets per hour. These systems produce the small apertures (600 μm to 1 mm) required by osmotic pump tablets with the necessary dimensional tolerances and cosmetic appearance—making laser drilling the technology of choice for modern pharmaceutical tablet production.

In addition to their high speeds, non-contact laser systems achieve an infinite number of aperture sizes and pattern variations. They also react favorably with medications and their carrier materials during the drilling process. Pairing your laser system with vision capabilities lets you control aperture quality with even greater precision while catching mis-drilled tablets.

CMS Laser is a leading industry innovator in tablet drilling systems for pharmaceutical companies. Our experience with high-speed, reliable laser systems makes us the best choice for drilling your tablets and capsules.

Advantages

  • Our CMS configuration lets you track tablets and minimize tablet breakage—resulting in better aperture quality over the range of sizes
  • Integrated vision systems improve your ability to track tablets and misplaced drill sites—improving yields
  • The CMS handling system keeps tablet changeovers to a minimum—requiring only minor adjustments to the bowl feeder and conveyor system. The result is higher uptime and a lower cost of ownership. Other systems, by contrast, require time consuming belt or wheel changes.
  • Minimal maintenance and cleaning requirements
  • System capabilities let you drill multiple apertures per tablet side, as well as process bi- or single-color tablets
  • Single laser systems have an average throughput of 50,000 to 70,000 tablets—and are capable of 100,000 tablets per hour
  • Single laser systems reduce maintenance and power consumption needs compared to dual-laser configurations
  • The CMS system orients bi-color tablets “drill side up” for tablets entering the conveyor and laser drilling area. It can also drill one or multiple apertures on a single side.
  • The system drills apertures between 0.3 to 2 millimeters—but can handle larger diameters up to 13 millimeters
  • Minimal changeover times between tablet sizes lower your costs by eliminating the need for multiple systems
  • Optional vision systems inspect the number, location and size of drilled apertures. Tablets that fail the vision inspection are rejected and separated from properly drilled tablets.

System Examples

  • Fully automated tablet handler and laser driller
  • Vision inspection systems—200 percent inspection
  • Reject verification
  • Safety interlocks—CDRH Class I compliance
  • Tablet sampling and collection bin
  • Product changeover time less than 45 minutes
  • Software validation
  • 316L Stainless Steel or FDA-approved contact surfaces
  • Installation and operational qualification
  • Fume evacuation
  • Self-contained cooling
  • Standard aperture diameters—0.3 to 2.0 millimeters
  • Average output—140,000 tablets per hour
  • Tablet shape—biconvex circular tablets
  • Range of tablet sizes—7.0 to 13.0 millimeters, with larger sizes available
  • Tablet appearance—bi-colored round biconvex. Single colors and layers also available.
  • CFR 21 Part 11 compliance for electronic signatures and audit logs
  • Fully automated tablet handler and laser driller
  • Vision inspection system
  • Reject verification
  • Safety interlocks—CDRH Class I compliance
  • Minimal part changes between product sizes
  • Product changeover time less than 45 minutes
  • Software validation
  • 316L Stainless Steel or FDA-approved contact surfaces
  • Installation and operational qualification
  • Fume evacuation
  • Self-contained cooling
  • One or multiple apertures
  • Standard aperture diameters—0.3 to 2.0 millimeters
  • Average output—10,000 tablets per hour
  • Tablet shape—biconvex circular tablets
  • Range of tablet sizes—7.0 to 13.0 millimeters, with larger sizes available
  • Tablet appearance—bi-colored round biconvex. Single colors and layers also available.
  • Designed for R&D development, trial runs, registration lots and production lots
  • CFR 21 Part 11 compliance for electronic signatures and audit logs
  • Operators hand-load trays drill side facing up. While the first tray is processing, a second tray can be loaded—increasing throughput
  • Multiple apertures per side
  • Aperture diameters—0.2 to 2 millimeters
  • Table shape—biconvex, circular, ROD, LCT and caplet. We review additional shapes and sizes for compatibility.
  • Class I operator safety
  • LaserDrill32 Integrated Drilling Software
  • Self-contained cooling
  • Stainless steel fume extraction system
  • Optional features—vision inspection station, IQ, OQ and PQ support and documentation, CFR 21 Part 11 compliance for signature and audit logs, and X-Y table for increased throughput

Videos

TD-140 Pharmaceutical Tablet Drilling System

TD-70 Pharmaceutical Tablet Driller

Pharmaceutical Tablet Drilling System for Research and Development

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